A mitochondrial-derived peptide studied for metabolic regulation, exercise performance, and insulin sensitivity.
MOTS-c Protocol
Mitochondrial · Mitochondrial Health, Performance, Longevity
Protocol Details
Dose
50 units (5mg)
Frequency
2 days / week
Administration
Subcutaneous
Timing
AM
Vial Size
10mg
Reconstitution
1mL Bacteriostatic Water
Cycle Length
4 week cycle every 4 months, for a total of 3x per year
Vials / Month
4
Vials / Cycle
4
If fatigue or worsening fatigue on MOTS-c is noticed some of the following may be an underlying issue: 1) Adrenal insufficiency 2) Under-treated or untreated hypothyroidism 3) Nutritional deficit (calories, iron) 4) Dose too high for their metabolic reserve 5) Impaired Methylation Finding the underlying cause is important, do not ignore.
Benefits
- Studied for enhancing insulin sensitivity and glucose regulation
- Explored for improving exercise capacity and physical performance
- May support metabolic homeostasis and fat oxidation
- Researched for anti-aging effects at the cellular level
- Studied for activating AMPK pathway (cellular energy sensor)
How it Works
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome (12S rRNA gene).
It activates AMPK, the master metabolic regulator sensing cellular energy status.
AMPK activation promotes glucose uptake, fat oxidation, and mitochondrial biogenesis.
It translocates to the nucleus during metabolic stress, directly regulating gene expression.
This protocol is an educational reference only, not medical advice. Consult a licensed clinician before beginning any peptide protocol.
Questions about MOTS-c?
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